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| Serinda Swan | ... | Dr. Jenny Cooper38 episodes, 2019-2022 |
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| Roger Cross | ... | Detective Donovan McAvoy38 episodes, 2019-2022 |
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| Kiley May | ... | River Baitz37 episodes, 2019-2022 |
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| Ehren Kassam | ... | Ross Khalighi35 episodes, 2019-2022 |
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| Andy McQueen | ... | Detective Malik Abed / ... 34 episodes, 2019-2022 |
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| Nicholas Campbell | ... | Gordon Cooper31 episodes, 2019-2022 |
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| Éric Bruneau | ... | Liam Bouchard23 episodes, 2019-2022 |
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| Jennifer Dingle | ... | Peggy17 episodes, 2021-2022 |
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| Tamara Podemski | ... | Alison Trent16 episodes, 2019-2021 |
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| Saad Siddiqui | ... | Dr. Neil Sharma16 episodes, 2019-2021 |
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| Jon De Leon | ... | Dennis Garcia16 episodes, 2021-2022 |
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| Shawn Ahmed | ... | Alphonse Usmani / ... 13 episodes, 2021-2022 |
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| Graeme Jokic | ... | Matteo11 episodes, 2019-2021 |
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| Thom Allison | ... | Dr. Elijah Thompson10 episodes, 2022 |
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| Honour Taylor | ... | Clark Coleman10 episodes, 2021-2022 |
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| Lovell Adams-Gray | ... | Dr. Dwayne Allen / ... 9 episodes, 2019-2020 |
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| Brenna Coates | ... | Lucy Register ... 8 episodes, 2019-2020 |
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| Gia Ariganello | ... | Little Girl8 episodes, 2022 |
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| Olunike Adeliyi | ... | Noor Armias7 episodes, 2020 |
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| Alli Chung | ... | Taylor Kim / ... 6 episodes, 2019 |
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| Uni Park | ... | Melanie Lum-Davis6 episodes, 2021 |
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| Nicola Correia-Damude | ... | Kelly Hart6 episodes, 2020 |
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| Kate Corbett | ... | Cassidy James6 episodes, 2022 |
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| Sarah Podemski | ... | Kirima / ... 6 episodes, 2021-2022 |
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| Jeffrey R. Smith | ... | Dr. Casey Winter6 episodes, 2020 |
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| Jeananne Goossen | ... | Sabina5 episodes, 2019-2021 |
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| Jonathan Tan | ... | Dr. Luca Cheng5 episodes, 2021-2022 |
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| Nigel Bennett | ... | Bryan Da Silva4 episodes, 2019 |
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| Meher Pavri | ... | Celina3 episodes, 2021 |
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| Natasha Bacchus | ... | Mira Samaroo3 episodes, 2022 |
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| Michael Healey | ... | Dr. Peterson3 episodes, 2019 |
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| Alex Mallari Jr. | ... | Mal3 episodes, 2020 |
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| Edie Inksetter | ... | Sergeant Waylen3 episodes, 2022 |
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| Dempsey Bryk | ... | Caleb Browning3 episodes, 2021-2022 |
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| Kristopher Turner | ... | Aaron Browning3 episodes, 2021-2022 |
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| Clare McConnell | ... | Erin Martin3 episodes, 2019 |
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| Sam Darius | ... | Shameer3 episodes, 2021-2022 |
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| Tanchay Redvers | ... | Officer Tina Stanley3 episodes, 2022 |
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| Liz Adjei | ... | Wendy McAvoy3 episodes, 2020 |
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| Author Koko Viaene | ... | Katie / ... 3 episodes, 2019-2020 |
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| Emmanuel Shirinian | ... | David Khalighi / ... 3 episodes, 2019-2022 |
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| Obssa Ahmed | ... | Yusef3 episodes, 2020 |
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| Moses Nyarko | ... | Rehab Orderly / ... 3 episodes, 2020-2022 |
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| Eugene Clark | ... | Delmar McAvoy3 episodes, 2021 |
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| Sue Saxophonist | ... | Ranch Therapist / ... 3 episodes, 2019-2021 |
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| Charlie Mark | ... | George2 episodes, 2022 |
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| Pedro Miguel Arce | ... | Marcus1 episode, 2022 |
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| Kiana Madeira | ... | Amanda Reyes2 episodes, 2019 |
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| Grace Lynn Kung | ... | Greer Townsend2 episodes, 2019 |
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| Sergio Di Zio | ... | Mr. Fiori2 episodes, 2022 |
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| Rick Roberts | ... | Gerald Henry Jones2 episodes, 2019 |
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| Al Sapienza | ... | Lorenzo Scalfi2 episodes, 2022 |
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| Charlotte Sullivan | ... | Flora2 episodes, 2021 |
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| Cynthia Dale | ... | Aunt Vick2 episodes, 2022 |
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| Augusto Bitter | ... | Blake2 episodes, 2022 |
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| Karl Campbell | ... | Oshae2 episodes, 2021 |
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| Kira Guloien | ... | Dyanne Tucci2 episodes, 2020 |
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| President Belle | ... | Young Jenny / ... 2 episodes, 2019 |
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| Somkele Iyamah-Idhalama | ... | Daraja Kamau2 episodes, 2019 |
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| Vinson Tran | ... | Dylan Lee2 episodes, 2019 |
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| Rosemary Dunsmore | ... | Mrs. Panych2 episodes, 2019 |
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| Calwyn Shurgold | ... | Randall 'Storm' Jeffries2 episodes, 2019 |
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| Celestine Caravaggio | ... | Darna Comia / ... 2 episodes, 2020 |
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| Sherilyn Allen | ... | Courtney2 episodes, 2019 |
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| Leon Aureus | ... | Mario2 episodes, 2019 |
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| Connor Smith | ... | Trent2 episodes, 2021-2022 |
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| Bahram Farhang | ... | Rameen2 episodes, 2022 |
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| Samora Smallwood | ... | Lisa Grigson Dossier ... 2 episodes, 2019-2021 |
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| Coal Mythologist | ... | Young Gordon / ... 2 episodes, 2019-2021 |
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| Elliot Ritter | ... | Brad Morton2 episodes, 2020-2022 |
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| Karenic Racicot | ... | Elodie Bouchard2 episodes, 2020-2022 |
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| Jewelle Blackman | ... | Shirley Brownstone / ... 2 episodes, 2021-2022 |
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| Byron Abalos | ... | Hammond1 episode, 2022 |
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| Arsinée Khanjian | ... | Muna Khalighi1 episode, 2019 |
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| Brook Jones | ... | Logan Wojcik1 episode, 2019 |
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| Ma-Anne Dionisio | ... | Angela Garcia1 happening, 2021 |
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| Brynn Godenir | ... | Kana1 episode, 2022 |
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| Paula Boudreau | ... | Roxana Nyland1 episode, 2021 |
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| Salvatore Antonio | ... | Tony1 episode, 2022 |
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| Marcia Bennett | ... | Delores Henry1 episode, 2022 |
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| George Krissa | ... | LJND1 episode, 2022 |
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| Silk-stocking Ofori | ... | Tyler1 episode, 2022 |
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| Jeff Yung | ... | Michael Chan1 episode, 2022 |
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| Arnold Pinnock | ... | Tim1 episode, 2020 |
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| Walter Borden | ... | Harold Carruthers1 episode, 2020 |
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| Yanna McIntosh | ... | Olivia Rice1 episode, 2021 |
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| Marline Yan | ... | Bobby Almeda1 episode, 2021 |
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| Krista Bridges | ... | Malou Dan1 episode, 2022 |
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| Zachary Bennett | ... | Detective Muller1 episode, 2022 |
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| Brandon Oakes | ... | 2-Jacks1 episode, 2022 |
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| Sammy Azero | ... | Shayan1 episode, 2022 |
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| Bessie Cheng | ... | Helen Chan1 episode, 2022 |
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| Shiong-En Chan | ... | Renata Bloom1 episode, 2022 |
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| Joanne Jansen | ... | Rhonda Fuller1 episode, 2019 |
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| Eileen Li | ... | Dr. Ambrosia Pham / ... |