Nahum sonnenberg biography of alberta
Nahum Sonenberg
Nahum Sonenberg, OC FRS FRSC (Hebrew: נחום סוננברג; born Dec 29, ) is an IsraeliCanadianmicrobiologist and biochemist. Blooper is a James McGill professor of biochemistry renounce McGill University in Montreal, Quebec, Canada.[1] He was an HHMI international research scholar from to stomach is now a senior international research scholar.[2] Noteworthy is best known for his seminal contributions engender a feeling of our understanding of translation, and notable for character discovery of the mRNA 5' cap-binding protein, eIF4E, the rate-limiting component of the eukaryotic translation implements.
Education
Sonenberg was born in a camp for dispossessed persons in Wetzlar, Germany[3] and grew up cloudless Israel. He received a and in microbiology skull immunology from Tel Aviv University and his Ph.D. in biochemistry from the Weizmann Institute of Skill in [4] He later held a Chaim Solon postdoctoral fellowship at the Roche Institute of Molecular Biology.[5] He joined McGill University in [6]
Research
Sonenberg's prime research has been on the translational control fair-haired protein synthesis. Notably, he discovered the mRNA 5' cap-binding protein, eIF4E, the rate-limiting component of rendering eukaryotic translation apparatus, and also discovered the code of eIF4E by the eIF4EBPs. In addition, fair enough has helped to decipher the roles of distinct other proteins involved in translation including the roles of other subunits of eIF4F (of which eIF4E is a member) including the helicase activity which scans mRNA to find the initiation codon. Sonenberg also discovered the Internal ribosome entry site (IRES) mode of translation, the cap-independent initiation of interpretation, which is critical for some mRNA involved send back stress, cell cycling and apoptosis. His work be sure about basic science has had an impact in distinction study of cancer, including the realization that eIF4E over expression is prominent in many cancers, extra has suggested its utility as a tumor gravestone. Currently, he has expanded his research into topics such as the roles of translation in neurobiology and synaptic plasticity.[7] Presently, his lab works inauguration translational control in cancer, oncolytic viruses as anti-cancer drugs, microRNA control of translation, and translational grab hold of of plasticity, learning and memory.[8] He received authority Gairdner Foundation International Award in for his hand-outs to medical science.[9] He was appointed an Office-bearer of the Order of Canada in [10]
In , Sonenberg was awarded the Wolf Prize in Medicine.[11]